home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-05 | 401.2 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000320| 03 00 b5 0e 00 00 35 36 | 00 00 00 01 da 71 03 00 |......56|.....q..|
|00000330| 56 10 00 00 35 37 00 00 | 00 01 30 82 03 00 84 0d |V...57..|..0.....|
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|00000360| 00 00 00 01 9f b5 03 00 | c7 0b 00 00 36 31 00 00 |........|....61..|
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|00000380| 60 d3 03 00 a6 12 00 00 | 36 33 00 00 00 01 06 e6 |`.......|63......|
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|000003d0| 00 00 00 01 3f 2e 04 00 | 4f 12 00 00 36 39 00 00 |....?...|O...69..|
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|000003f0| 63 4d 04 00 2e 0e 00 00 | 37 31 00 00 00 01 91 5b |cM......|71.....[|
|00000400| 04 00 73 16 00 00 37 32 | 00 00 00 01 04 72 04 00 |..s...72|.....r..|
|00000410| cd 17 00 00 37 33 00 00 | 00 01 d1 89 04 00 ca 0e |....73..|........|
|00000420| 00 00 37 34 00 00 00 01 | 9b 98 04 00 8c 0d 00 00 |..74....|........|
|00000430| 37 35 00 00 00 01 27 a6 | 04 00 9b 0e 00 00 37 36 |75....'.|......76|
|00000440| 00 00 00 01 c2 b4 04 00 | a7 14 00 00 37 37 00 00 |........|....77..|
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|00000460| 20 d6 04 00 aa 11 00 00 | 37 39 00 00 00 01 ca e7 | .......|79......|
|00000470| 04 00 52 11 00 00 38 30 | 00 00 00 01 1c f9 04 00 |..R...80|........|
|00000480| 9b 11 00 00 38 31 00 00 | 00 01 b7 0a 05 00 c0 0f |....81..|........|
|00000490| 00 00 38 32 00 00 00 01 | 77 1a 05 00 1b 13 00 00 |..82....|w.......|
|000004a0| 38 33 00 00 00 01 92 2d | 05 00 2b 11 00 00 38 34 |83.....-|..+...84|
|000004b0| 00 00 00 01 bd 3e 05 00 | f1 11 00 00 38 35 00 00 |.....>..|....85..|
|000004c0| 00 01 ae 50 05 00 a9 14 | 00 00 38 36 00 00 00 01 |...P....|..86....|
|000004d0| 57 65 05 00 32 0f 00 00 | 38 37 00 00 00 01 89 74 |We..2...|87.....t|
|000004e0| 05 00 3d 0c 00 00 38 38 | 00 00 00 01 c6 80 05 00 |..=...88|........|
|000004f0| 3f 0c 00 00 38 39 00 00 | 00 01 05 8d 05 00 fd 0d |?...89..|........|
|00000500| 00 00 39 30 00 00 00 01 | 02 9b 05 00 d4 14 00 00 |..90....|........|
|00000510| 39 31 00 00 00 01 d6 af | 05 00 b6 11 00 00 39 32 |91......|......92|
|00000520| 00 00 00 01 8c c1 05 00 | b8 0e 00 00 39 33 00 00 |........|....93..|
|00000530| 00 01 44 d0 05 00 7f 0b | 00 00 39 34 00 00 00 01 |..D.....|..94....|
|00000540| c3 db 05 00 06 0d 00 00 | 39 35 00 00 00 01 c9 e8 |........|95......|
|00000550| 05 00 48 1e 00 00 39 36 | 00 00 00 01 11 07 06 00 |..H...96|........|
|00000560| 93 0d 00 00 39 37 00 00 | 00 01 a4 14 06 00 1f 11 |....97..|........|
|00000570| 00 00 39 38 00 00 00 01 | c3 25 06 00 a3 0e 00 00 |..98....|.%......|
|00000580| 39 39 00 00 00 01 66 34 | 06 00 34 10 00 00 00 00 |99....f4|..4.....|
|00000590| 00 00 00 00 9a 44 06 00 | 00 00 00 00 24 55 6e 69 |.....D..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 32 33 30 30 7d |que_ID{Y|RB02300}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 41 6e 74 65 6e 61 74 |..$Title|{Antenat|
|000005c0| 61 6c 20 61 6e 64 20 49 | 6e 74 72 61 70 61 72 74 |al and I|ntrapart|
|000005d0| 75 6d 20 46 61 63 74 6f | 72 73 20 41 73 73 6f 63 |um Facto|rs Assoc|
|000005e0| 69 61 74 65 64 20 57 69 | 74 68 20 74 68 65 20 4f |iated Wi|th the O|
|000005f0| 63 63 75 72 72 65 6e 63 | 65 20 6f 66 0d 0a 53 65 |ccurrenc|e of..Se|
|00000600| 69 7a 75 72 65 73 20 69 | 6e 20 74 68 65 20 54 65 |izures i|n the Te|
|00000610| 72 6d 20 49 6e 66 61 6e | 74 7d 0d 0a 24 41 75 74 |rm Infan|t}..$Aut|
|00000620| 68 6f 72 7b 0d 0a 50 61 | 74 74 65 72 73 6f 6e 2c |hor{..Pa|tterson,|
|00000630| 20 43 41 0d 0a 47 72 61 | 76 65 73 2c 20 57 4c 0d | CA..Gra|ves, WL.|
|00000640| 0a 42 75 67 67 2c 20 47 | 0d 0a 53 61 73 73 6f 2c |.Bugg, G|..Sasso,|
|00000650| 20 53 43 0d 0a 42 72 61 | 6e 6e 2c 20 41 57 20 4a | SC..Bra|nn, AW J|
|00000660| 72 7d 0d 0a 24 41 66 66 | 69 6c 69 61 74 69 6f 6e |r}..$Aff|iliation|
|00000670| 7b 45 6d 6f 72 79 20 55 | 6e 69 76 7d 0d 0a 24 4a |{Emory U|niv}..$J|
|00000680| 6f 75 72 6e 61 6c 7b 4f | 62 73 74 65 74 20 47 79 |ournal{O|bstet Gy|
|00000690| 6e 65 63 6f 6c 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |necol}..|$Volume{|
|000006a0| 37 34 7d 0d 0a 24 50 61 | 67 65 7b 33 36 31 2d 33 |74}..$Pa|ge{361-3|
|000006b0| 36 35 7d 0d 0a 24 44 61 | 74 65 7b 31 39 38 39 7d |65}..$Da|te{1989}|
|000006c0| 0d 0a 24 59 42 56 6f 6c | 7b 31 39 39 31 20 59 65 |..$YBVol|{1991 Ye|
|000006d0| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 4e 65 6f 6e 61 |ar Book |of Neona|
|000006e0| 74 61 6c 20 61 6e 64 20 | 50 65 72 69 6e 61 74 61 |tal and |Perinata|
|000006f0| 6c 20 4d 65 64 69 63 69 | 6e 65 7d 0d 0a 24 43 68 |l Medici|ne}..$Ch|
|00000700| 61 70 74 65 72 7b 37 2d | 38 7d 0d 0a 24 59 42 45 |apter{7-|8}..$YBE|
|00000710| 64 69 74 6f 72 7b 44 72 | 73 2e 20 4b 6c 61 75 73 |ditor{Dr|s. Klaus|
|00000720| 20 61 6e 64 20 46 61 6e | 61 72 6f 66 66 7d 0d 0a | and Fan|aroff}..|
|00000730| 24 54 61 62 6c 65 7b 54 | 61 62 6c 65 20 4f 6d 69 |$Table{T|able Omi|
|00000740| 74 74 65 64 7d 0d 0a 24 | 43 6f 6d 6d 65 6e 74 61 |tted}..$|Commenta|
|00000750| 74 6f 72 7b 7d 0d 0a 0d | 0a 43 6f 70 79 72 69 67 |tor{}...|.Copyrig|
|00000760| 68 74 20 28 43 29 20 59 | 65 61 72 20 42 6f 6f 6b |ht (C) Y|ear Book|
|00000770| 20 4d 65 64 69 63 61 6c | 20 50 75 62 6c 69 73 68 | Medical| Publish|
|00000780| 65 72 73 2c 20 49 6e 63 | 2e 20 31 39 39 31 0d 0a |ers, Inc|. 1991..|
|00000790| 0d 0a 31 39 39 31 20 59 | 65 61 72 20 42 6f 6f 6b |..1991 Y|ear Book|
|000007a0| 20 6f 66 20 4e 65 6f 6e | 61 74 61 6c 20 61 6e 64 | of Neon|atal and|
|000007b0| 20 50 65 72 69 6e 61 74 | 61 6c 20 4d 65 64 69 63 | Perinat|al Medic|
|000007c0| 69 6e 65 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 37 |ine....C|hapter 7|
|000007d0| 20 2d 2d 20 54 68 65 20 | 4e 65 72 76 6f 75 73 20 | -- The |Nervous |
|000007e0| 53 79 73 74 65 6d 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |System..|..------|
|000007f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000820| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000830| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 41 6e 74 65 6e 61 |--------|..Antena|
|00000840| 74 61 6c 20 61 6e 64 20 | 49 6e 74 72 61 70 61 72 |tal and |Intrapar|
|00000850| 74 75 6d 20 46 61 63 74 | 6f 72 73 20 41 73 73 6f |tum Fact|ors Asso|
|00000860| 63 69 61 74 65 64 20 57 | 69 74 68 20 74 68 65 20 |ciated W|ith the |
|00000870| 4f 63 63 75 72 72 65 6e | 63 65 20 6f 66 20 53 65 |Occurren|ce of Se|
|00000880| 69 7a 75 72 65 73 0d 0a | 69 6e 20 74 68 65 20 54 |izures..|in the T|
|00000890| 65 72 6d 20 49 6e 66 61 | 6e 74 0d 0a 0d 0a 50 61 |erm Infa|nt....Pa|
|000008a0| 74 74 65 72 73 6f 6e 20 | 43 41 3b 20 47 72 61 76 |tterson |CA; Grav|
|000008b0| 65 73 20 57 4c 3b 20 42 | 75 67 67 20 47 3b 20 53 |es WL; B|ugg G; S|
|000008c0| 61 73 73 6f 20 53 43 3b | 20 42 72 61 6e 6e 20 41 |asso SC;| Brann A|
|000008d0| 57 20 4a 72 0d 0a 28 45 | 6d 6f 72 79 20 55 6e 69 |W Jr..(E|mory Uni|
|000008e0| 76 29 0d 0a 4f 62 73 74 | 65 74 20 47 79 6e 65 63 |v)..Obst|et Gynec|
|000008f0| 6f 6c 20 37 34 3a 33 36 | 31 2d 33 36 35 2c 20 31 |ol 74:36|1-365, 1|
|00000900| 39 38 39 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |989..---|--------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000920| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000950| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00000960| 0a 0d 0a 20 20 20 20 20 | 49 6e 20 70 72 65 76 69 |... |In previ|
|00000970| 6f 75 73 20 69 6e 76 65 | 73 74 69 67 61 74 69 6f |ous inve|stigatio|
|00000980| 6e 73 20 61 6e 20 61 73 | 73 6f 63 69 61 74 69 6f |ns an as|sociatio|
|00000990| 6e 20 62 65 74 77 65 65 | 6e 20 65 61 72 6c 79 20 |n betwee|n early |
|000009a0| 6e 65 6f 6e 61 74 61 6c | 20 73 65 69 7a 75 72 65 |neonatal| seizure|
|000009b0| 73 0d 0a 61 6e 64 20 70 | 65 72 69 6e 61 74 61 6c |s..and p|erinatal|
|000009c0| 20 65 76 65 6e 74 73 2c | 20 70 61 72 74 69 63 75 | events,| particu|
|000009d0| 6c 61 72 6c 79 20 61 73 | 70 68 79 78 69 61 2c 20 |larly as|phyxia, |
|000009e0| 68 61 73 20 62 65 65 6e | 20 64 65 66 69 6e 65 64 |has been| defined|
|000009f0| 2e 20 20 54 6f 20 69 64 | 65 6e 74 69 66 79 0d 0a |. To id|entify..|
|00000a00| 61 6e 74 65 6e 61 74 61 | 6c 20 61 6e 64 20 69 6e |antenata|l and in|
|00000a10| 74 72 61 70 61 72 74 75 | 6d 20 66 61 63 74 6f 72 |trapartu|m factor|
|00000a20| 73 20 61 73 73 6f 63 69 | 61 74 65 64 20 77 69 74 |s associ|ated wit|
|00000a30| 68 20 73 65 69 7a 75 72 | 65 73 20 69 6e 20 74 65 |h seizur|es in te|
|00000a40| 72 6d 20 6e 65 77 62 6f | 72 6e 73 2c 0d 0a 34 30 |rm newbo|rns,..40|
|00000a50| 20 74 65 72 6d 20 69 6e | 66 61 6e 74 73 20 77 68 | term in|fants wh|
|00000a60| 6f 20 68 61 64 20 73 65 | 69 7a 75 72 65 73 20 77 |o had se|izures w|
|00000a70| 69 74 68 69 6e 20 37 32 | 20 68 6f 75 72 73 20 6f |ithin 72| hours o|
|00000a80| 66 20 62 69 72 74 68 20 | 77 65 72 65 20 63 6f 6d |f birth |were com|
|00000a90| 70 61 72 65 64 20 77 69 | 74 68 0d 0a 34 30 30 20 |pared wi|th..400 |
|00000aa0| 63 6f 6e 74 72 6f 6c 73 | 20 62 79 20 75 73 69 6e |controls| by usin|
|00000ab0| 67 20 6c 6f 67 69 73 74 | 69 63 20 72 65 67 72 65 |g logist|ic regre|
|00000ac0| 73 73 69 6f 6e 20 61 6e | 61 6c 79 73 69 73 2e 0d |ssion an|alysis..|
|00000ad0| 0a 20 20 20 20 20 54 68 | 65 20 72 69 73 6b 20 6f |. Th|e risk o|
|00000ae0| 66 20 65 61 72 6c 79 20 | 6e 65 6f 6e 61 74 61 6c |f early |neonatal|
|00000af0| 20 73 65 69 7a 75 72 65 | 73 20 69 6e 20 74 68 65 | seizure|s in the|
|00000b00| 73 65 20 74 65 72 6d 20 | 69 6e 66 61 6e 74 73 20 |se term |infants |
|00000b10| 77 61 73 20 31 2e 30 35 | 20 70 65 72 0d 0a 31 2c |was 1.05| per..1,|
|00000b20| 30 30 30 20 6c 69 76 65 | 20 74 65 72 6d 20 62 69 |000 live| term bi|
|00000b30| 72 74 68 73 2e 20 20 46 | 61 63 74 6f 72 73 20 61 |rths. F|actors a|
|00000b40| 73 73 6f 63 69 61 74 65 | 64 20 77 69 74 68 20 69 |ssociate|d with i|
|00000b50| 6e 63 72 65 61 73 65 64 | 20 72 69 73 6b 20 6f 66 |ncreased| risk of|
|00000b60| 20 73 65 69 7a 75 72 65 | 73 20 69 6e 0d 0a 74 65 | seizure|s in..te|
|00000b70| 72 6d 20 69 6e 66 61 6e | 74 73 20 77 65 72 65 20 |rm infan|ts were |
|00000b80| 61 6e 74 65 6e 61 74 61 | 6c 20 61 6e 65 6d 69 61 |antenata|l anemia|
|00000b90| 2c 20 61 6e 74 65 6e 61 | 74 61 6c 20 62 6c 65 65 |, antena|tal blee|
|00000ba0| 64 69 6e 67 2c 20 61 73 | 74 68 6d 61 2c 0d 0a 6d |ding, as|thma,..m|
|00000bb0| 65 63 6f 6e 69 75 6d 2d | 73 74 61 69 6e 65 64 20 |econium-|stained |
|00000bc0| 61 6d 6e 69 6f 74 69 63 | 20 66 6c 75 69 64 2c 20 |amniotic| fluid, |
|00000bd0| 70 72 65 73 65 6e 74 61 | 74 69 6f 6e 20 6f 74 68 |presenta|tion oth|
|00000be0| 65 72 20 74 68 61 6e 20 | 6f 63 63 69 70 75 74 20 |er than |occiput |
|00000bf0| 61 6e 74 65 72 69 6f 72 | 2c 0d 0a 66 65 74 61 6c |anterior|,..fetal|
|00000c00| 20 64 69 73 74 72 65 73 | 73 2c 20 61 6e 64 20 73 | distres|s, and s|
|00000c10| 68 6f 75 6c 64 65 72 20 | 64 79 73 74 6f 63 69 61 |houlder |dystocia|
|00000c20| 2e 20 20 54 68 65 20 69 | 6e 64 69 76 69 64 75 61 |. The i|ndividua|
|00000c30| 6c 20 70 72 65 64 69 63 | 74 69 76 65 20 76 61 6c |l predic|tive val|
|00000c40| 75 65 20 6f 66 0d 0a 74 | 68 65 73 65 20 66 61 63 |ue of..t|hese fac|
|00000c50| 74 6f 72 73 20 77 61 73 | 20 6c 6f 77 20 28 74 61 |tors was| low (ta|
|00000c60| 62 6c 65 29 2c 20 62 75 | 74 20 74 68 65 20 63 6f |ble), bu|t the co|
|00000c70| 6d 62 69 6e 61 74 69 6f | 6e 20 6f 66 20 74 68 65 |mbinatio|n of the|
|00000c80| 73 65 20 66 61 63 74 6f | 72 73 20 69 6e 20 61 0d |se facto|rs in a.|
|00000c90| 0a 6c 6f 67 69 73 74 69 | 63 20 72 65 67 72 65 73 |.logisti|c regres|
|00000ca0| 73 69 6f 6e 20 6d 6f 64 | 65 6c 20 69 64 65 6e 74 |sion mod|el ident|
|00000cb0| 69 66 69 65 64 20 61 20 | 67 72 6f 75 70 20 6f 66 |ified a |group of|
|00000cc0| 20 69 6e 66 61 6e 74 73 | 20 66 6f 72 20 77 68 6f | infants| for who|
|00000cd0| 6d 20 74 68 65 20 6f 64 | 64 73 20 6f 66 0d 0a 68 |m the od|ds of..h|
|00000ce0| 61 76 69 6e 67 20 61 20 | 73 65 69 7a 75 72 65 20 |aving a |seizure |
|00000cf0| 77 65 72 65 20 61 70 70 | 72 6f 78 69 6d 61 74 65 |were app|roximate|
|00000d00| 6c 79 20 31 20 69 6e 20 | 31 30 30 2e 0d 0a 20 20 |ly 1 in |100... |
|00000d10| 20 20 20 54 68 69 73 20 | 61 6e 61 6c 79 73 69 73 | This |analysis|
|00000d20| 20 63 6f 6e 66 69 72 6d | 65 64 20 61 20 73 74 72 | confirm|ed a str|
|00000d30| 6f 6e 67 20 61 73 73 6f | 63 69 61 74 69 6f 6e 20 |ong asso|ciation |
|00000d40| 62 65 74 77 65 65 6e 20 | 73 65 69 7a 75 72 65 73 |between |seizures|
|00000d50| 20 61 6e 64 20 66 61 63 | 74 6f 72 73 0d 0a 74 68 | and fac|tors..th|
|00000d60| 61 74 20 69 6e 63 72 65 | 61 73 65 20 74 68 65 20 |at incre|ase the |
|00000d70| 72 69 73 6b 20 6f 66 20 | 66 65 74 61 6c 20 61 73 |risk of |fetal as|
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|00001290| 44 61 74 65 7b 31 39 39 | 30 7d 0d 0a 24 59 42 56 |Date{199|0}..$YBV|
|000012a0| 6f 6c 7b 31 39 39 31 20 | 59 65 61 72 20 42 6f 6f |ol{1991 |Year Boo|
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|000012f0| 44 72 73 2e 20 4b 6c 61 | 75 73 20 61 6e 64 20 46 |Drs. Kla|us and F|
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|00001370| 20 4e 65 6f 6e 61 74 61 | 6c 20 61 6e 64 20 50 65 | Neonata|l and Pe|
|00001380| 72 69 6e 61 74 61 6c 20 | 4d 65 64 69 63 69 6e 65 |rinatal |Medicine|
|00001390| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 37 20 2d 2d |....Chap|ter 7 --|
|000013a0| 20 54 68 65 20 4e 65 72 | 76 6f 75 73 20 53 79 73 | The Ner|vous Sys|
|000013b0| 74 65 6d 0d 0a 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d |tem....-|--------|
|000013c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000013d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000013e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000013f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001400| 2d 2d 2d 2d 2d 0d 0a 4e | 65 6f 6e 61 74 61 6c 20 |-----..N|eonatal |
|00001410| 43 6f 63 61 69 6e 65 2d | 52 65 6c 61 74 65 64 20 |Cocaine-|Related |
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|00001430| 65 72 20 4c 44 3b 20 4c | 6f 63 6b 65 20 47 45 3b |er LD; L|ocke GE;|
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|00001450| 73 6f 6e 20 4c 0d 0a 28 | 4b 69 6e 67 2f 44 72 65 |son L..(|King/Dre|
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|00001470| 6e 67 65 6c 65 73 29 0d | 0a 4a 20 43 68 69 6c 64 |ngeles).|.J Child|
|00001480| 20 4e 65 75 72 6f 6c 20 | 35 3a 36 30 2d 36 34 2c | Neurol |5:60-64,|
|00001490| 20 31 39 39 30 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1990..-|--------|
|000014a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000014b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000014c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000014d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000014e0| 2d 2d 2d 2d 2d 0d 0a 0d | 0a 41 62 73 74 72 61 63 |-----...|.Abstrac|
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|00003650| 20 31 39 39 31 0d 0a 0d | 0a 31 39 39 31 20 59 65 | 1991...|.1991 Ye|
|00003660| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 4e 65 6f 6e 61 |ar Book |of Neona|
|00003670| 74 61 6c 20 61 6e 64 20 | 50 65 72 69 6e 61 74 61 |tal and |Perinata|
|00003680| 6c 20 4d 65 64 69 63 69 | 6e 65 0d 0a 0d 0a 43 68 |l Medici|ne....Ch|
|00003690| 61 70 74 65 72 20 37 20 | 2d 2d 20 54 68 65 20 4e |apter 7 |-- The N|
|000036a0| 65 72 76 6f 75 73 20 53 | 79 73 74 65 6d 0d 0a 0d |ervous S|ystem...|
|000036b0| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|000036c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000036d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000036e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000036f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|00003700| 0a 4e 65 75 72 6f 73 6f | 6e 6f 67 72 61 70 68 69 |.Neuroso|nographi|
|00003710| 63 20 46 65 61 74 75 72 | 65 73 20 6f 66 20 50 65 |c Featur|es of Pe|
|00003720| 72 69 76 65 6e 74 72 69 | 63 75 6c 61 72 20 45 63 |riventri|cular Ec|
|00003730| 68 6f 64 65 6e 73 69 74 | 69 65 73 20 41 73 73 6f |hodensit|ies Asso|
|00003740| 63 69 61 74 65 64 20 57 | 69 74 68 0d 0a 43 65 72 |ciated W|ith..Cer|
|00003750| 65 62 72 61 6c 20 50 61 | 6c 73 79 20 69 6e 20 50 |ebral Pa|lsy in P|
|00003760| 72 65 74 65 72 6d 20 49 | 6e 66 61 6e 74 73 0d 0a |reterm I|nfants..|
|00003770| 0d 0a 50 69 64 63 6f 63 | 6b 20 46 53 3b 20 47 72 |..Pidcoc|k FS; Gr|
|00003780| 61 7a 69 61 6e 69 20 4c | 4a 3b 20 53 74 61 6e 6c |aziani L|J; Stanl|
|00003790| 65 79 20 43 3b 20 4d 69 | 74 63 68 65 6c 6c 20 44 |ey C; Mi|tchell D|
|000037a0| 47 3b 20 4d 65 72 74 6f | 6e 20 44 0d 0a 28 54 68 |G; Merto|n D..(Th|
|000037b0| 6f 6d 61 73 20 4a 65 66 | 66 65 72 73 6f 6e 20 55 |omas Jef|ferson U|
|000037c0| 6e 69 76 20 48 6f 73 70 | 2c 20 50 68 69 6c 61 64 |niv Hosp|, Philad|
|000037d0| 65 6c 70 68 69 61 29 0d | 0a 4a 20 50 65 64 69 61 |elphia).|.J Pedia|
|000037e0| 74 72 20 31 31 36 3a 34 | 31 37 2d 34 32 32 2c 20 |tr 116:4|17-422, |
|000037f0| 31 39 39 30 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1990..--|--------|
|00003800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003820| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003830| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003840| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00003850| 0d 0a 0d 0a 20 20 20 20 | 20 42 65 63 61 75 73 65 |.... | Because|
|00003860| 20 70 65 72 69 76 65 6e | 74 72 69 63 75 6c 61 72 | periven|tricular|
|00003870| 20 6c 65 75 6b 6f 6d 61 | 6c 61 63 69 61 20 70 72 | leukoma|lacia pr|
|00003880| 6f 62 61 62 6c 79 20 72 | 65 70 72 65 73 65 6e 74 |obably r|epresent|
|00003890| 73 20 74 68 65 20 72 65 | 73 75 6c 74 73 20 6f 66 |s the re|sults of|
|000038a0| 0d 0a 69 73 63 68 65 6d | 69 63 20 69 6e 6a 75 72 |..ischem|ic injur|
|000038b0| 79 20 74 6f 20 73 75 62 | 63 6f 72 74 69 63 61 6c |y to sub|cortical|
|000038c0| 20 77 68 69 74 65 20 6d | 61 74 74 65 72 2c 20 74 | white m|atter, t|
|000038d0| 68 65 20 72 69 73 6b 20 | 6f 66 20 63 65 72 65 62 |he risk |of cereb|
|000038e0| 72 61 6c 20 70 61 6c 73 | 79 20 77 61 73 0d 0a 64 |ral pals|y was..d|
|000038f0| 65 74 65 72 6d 69 6e 65 | 64 20 69 6e 20 31 32 37 |etermine|d in 127|
|00003900| 20 70 72 65 74 65 72 6d | 20 69 6e 66 61 6e 74 73 | preterm| infants|
|00003910| 20 77 68 6f 73 65 20 6e | 65 6f 6e 61 74 61 6c 20 | whose n|eonatal |
|00003920| 6e 65 75 72 6f 73 6f 6e | 6f 67 72 61 6d 73 20 64 |neuroson|ograms d|
|00003930| 65 6d 6f 6e 73 74 72 61 | 74 65 0d 0a 70 65 72 69 |emonstra|te..peri|
|00003940| 76 65 6e 74 72 69 63 75 | 6c 61 72 20 65 63 68 6f |ventricu|lar echo|
|00003950| 67 65 6e 69 63 20 61 62 | 6e 6f 72 6d 61 6c 69 74 |genic ab|normalit|
|00003960| 69 65 73 2e 20 20 54 68 | 65 20 69 6e 66 61 6e 74 |ies. Th|e infant|
|00003970| 73 20 68 61 64 20 73 6f | 6e 6f 67 72 61 70 68 69 |s had so|nographi|
|00003980| 63 20 65 76 69 64 65 6e | 63 65 0d 0a 6f 66 20 69 |c eviden|ce..of i|
|00003990| 6e 63 72 65 61 73 65 64 | 20 70 65 72 69 76 65 6e |ncreased| periven|
|000039a0| 74 72 69 63 75 6c 61 72 | 20 65 63 68 6f 64 65 6e |tricular| echoden|
|000039b0| 73 69 74 79 20 61 6e 64 | 20 77 65 72 65 20 66 6f |sity and| were fo|
|000039c0| 6c 6c 6f 77 65 64 20 75 | 70 20 74 6f 20 61 67 65 |llowed u|p to age|
|000039d0| 73 20 31 38 20 74 6f 20 | 32 34 0d 0a 6d 6f 6e 74 |s 18 to |24..mont|
|000039e0| 68 73 2e 0d 0a 20 20 20 | 20 20 53 70 61 73 74 69 |hs... | Spasti|
|000039f0| 63 20 63 65 72 65 62 72 | 61 6c 20 70 61 6c 73 79 |c cerebr|al palsy|
|00003a00| 20 77 61 73 20 64 69 61 | 67 6e 6f 73 65 64 20 69 | was dia|gnosed i|
|00003a10| 6e 20 32 36 20 69 6e 66 | 61 6e 74 73 2c 20 61 6c |n 26 inf|ants, al|
|00003a20| 6c 20 6f 66 20 77 68 6f | 6d 20 68 61 64 0d 0a 6d |l of who|m had..m|
|00003a30| 6f 64 65 72 61 74 65 20 | 74 6f 20 73 65 76 65 72 |oderate |to sever|
|00003a40| 65 20 70 65 72 69 76 65 | 6e 74 72 69 63 75 6c 61 |e perive|ntricula|
|00003a50| 72 20 65 63 68 6f 64 65 | 6e 73 69 74 69 65 73 20 |r echode|nsities |
|00003a60| 73 75 70 65 72 69 6f 72 | 20 61 6e 64 20 6c 61 74 |superior| and lat|
|00003a70| 65 72 61 6c 20 74 6f 20 | 74 68 65 0d 0a 63 61 75 |eral to |the..cau|
|00003a80| 64 6f 74 68 61 6c 61 6d | 69 63 20 6e 6f 74 63 68 |dothalam|ic notch|
|00003a90| 2e 20 20 53 69 6d 69 6c | 61 72 20 63 68 61 6e 67 |. Simil|ar chang|
|00003aa0| 65 73 20 77 65 72 65 20 | 70 72 65 73 65 6e 74 20 |es were |present |
|00003ab0| 69 6e 20 33 36 20 69 6e | 66 61 6e 74 73 20 77 69 |in 36 in|fants wi|
|00003ac0| 74 68 6f 75 74 0d 0a 63 | 65 72 65 62 72 61 6c 20 |thout..c|erebral |
|00003ad0| 70 61 6c 73 79 2c 20 31 | 39 20 6f 66 20 77 68 6f |palsy, 1|9 of who|
|00003ae0| 6d 20 68 61 64 20 63 79 | 73 74 20 66 6f 72 6d 61 |m had cy|st forma|
|00003af0| 74 69 6f 6e 2e 20 20 49 | 6e 74 72 61 63 72 61 6e |tion. I|ntracran|
|00003b00| 69 61 6c 20 68 65 6d 6f | 72 72 68 61 67 65 20 77 |ial hemo|rrhage w|
|00003b10| 61 73 0d 0a 6d 6f 72 65 | 20 66 72 65 71 75 65 6e |as..more| frequen|
|00003b20| 74 20 69 6e 20 69 6e 66 | 61 6e 74 73 20 69 6e 20 |t in inf|ants in |
|00003b30| 77 68 6f 6d 20 63 65 72 | 65 62 72 61 6c 20 70 61 |whom cer|ebral pa|
|00003b40| 6c 73 79 20 64 65 76 65 | 6c 6f 70 65 64 2c 20 62 |lsy deve|loped, b|
|00003b50| 75 74 20 64 69 64 20 6e | 6f 74 0d 0a 69 6e 63 72 |ut did n|ot..incr|
|00003b60| 65 61 73 65 20 74 68 65 | 20 70 72 65 64 69 63 74 |ease the| predict|
|00003b70| 69 76 65 20 76 61 6c 75 | 65 20 6f 66 20 6e 65 75 |ive valu|e of neu|
|00003b80| 72 6f 73 6f 6e 6f 67 72 | 61 70 68 79 2e 20 20 41 |rosonogr|aphy. A|
|00003b90| 6c 6c 20 32 34 20 69 6e | 66 61 6e 74 73 20 77 69 |ll 24 in|fants wi|
|00003ba0| 74 68 0d 0a 64 69 70 61 | 72 65 73 69 73 20 6f 72 |th..dipa|resis or|
|00003bb0| 20 71 75 61 64 72 69 70 | 61 72 65 73 69 73 20 68 | quadrip|aresis h|
|00003bc0| 61 64 20 63 79 73 74 73 | 20 61 6e 64 20 70 65 72 |ad cysts| and per|
|00003bd0| 69 76 65 6e 74 72 69 63 | 75 6c 61 72 20 65 63 68 |iventric|ular ech|
|00003be0| 6f 64 65 6e 73 69 74 69 | 65 73 2e 0d 0a 20 20 20 |odensiti|es... |
|00003bf0| 20 20 53 6f 6e 6f 67 72 | 61 70 68 69 63 20 61 62 | Sonogr|aphic ab|
|00003c00| 6e 6f 72 6d 61 6c 69 74 | 69 65 73 20 69 6e 20 74 |normalit|ies in t|
|00003c10| 68 65 20 61 6e 74 65 72 | 69 6f 72 20 70 61 72 69 |he anter|ior pari|
|00003c20| 65 74 61 6c 20 72 65 67 | 69 6f 6e 20 61 72 65 20 |etal reg|ion are |
|00003c30| 68 65 6c 70 66 75 6c 20 | 69 6e 0d 0a 70 72 65 64 |helpful |in..pred|
|00003c40| 69 63 74 69 6e 67 20 74 | 68 65 20 64 65 76 65 6c |icting t|he devel|
|00003c50| 6f 70 6d 65 6e 74 20 6f | 66 20 63 65 72 65 62 72 |opment o|f cerebr|
|00003c60| 61 6c 20 70 61 6c 73 79 | 20 28 74 61 62 6c 65 29 |al palsy| (table)|
|00003c70| 2e 20 20 41 6c 74 68 6f | 75 67 68 20 73 65 6e 73 |. Altho|ugh sens|
|00003c80| 69 74 69 76 65 2c 0d 0a | 70 65 72 69 76 65 6e 74 |itive,..|perivent|
|00003c90| 72 69 63 75 6c 61 72 20 | 65 63 68 6f 64 65 6e 73 |ricular |echodens|
|00003ca0| 69 74 79 20 69 73 20 6e | 6f 74 20 76 65 72 79 20 |ity is n|ot very |
|00003cb0| 73 70 65 63 69 66 69 63 | 20 66 6f 72 20 63 65 72 |specific| for cer|
|00003cc0| 65 62 72 61 6c 20 70 61 | 6c 73 79 2e 20 20 53 70 |ebral pa|lsy. Sp|
|00003cd0| 61 73 74 69 63 0d 0a 63 | 65 72 65 62 72 61 6c 20 |astic..c|erebral |
|00003ce0| 70 61 6c 73 79 20 69 73 | 20 75 6e 6c 69 6b 65 6c |palsy is| unlikel|
|00003cf0| 79 20 74 6f 20 64 65 76 | 65 6c 6f 70 20 69 6e 20 |y to dev|elop in |
|00003d00| 74 68 65 20 61 62 73 65 | 6e 63 65 20 6f 66 20 70 |the abse|nce of p|
|00003d10| 65 72 69 76 65 6e 74 72 | 69 63 75 6c 61 72 0d 0a |eriventr|icular..|
|00003d20| 65 63 68 6f 64 65 6e 73 | 69 74 69 65 73 20 61 6e |echodens|ities an|
|00003d30| 64 20 63 79 73 74 20 66 | 6f 72 6d 61 74 69 6f 6e |d cyst f|ormation|
|00003d40| 2c 20 69 66 20 67 72 61 | 64 65 20 49 56 20 69 6e |, if gra|de IV in|
|00003d50| 74 72 61 63 72 61 6e 69 | 61 6c 20 68 65 6d 6f 72 |tracrani|al hemor|
|00003d60| 72 68 61 67 65 20 61 6c | 73 6f 20 69 73 0d 0a 61 |rhage al|so is..a|
|00003d70| 62 73 65 6e 74 2e 0d 0a | 0d 0a 50 6f 73 74 2d 43 |bsent...|..Post-C|
|00003d80| 6f 6d 6d 65 6e 74 0d 0a | 0d 0a 20 20 20 20 20 43 |omment..|.. C|
|00003d90| 72 61 6e 69 61 6c 20 75 | 6c 74 72 61 73 6f 6e 6f |ranial u|ltrasono|
|00003da0| 67 72 61 70 68 79 20 69 | 73 20 6f 66 20 69 6d 6d |graphy i|s of imm|
|00003db0| 65 6e 73 65 20 76 61 6c | 75 65 20 69 6e 20 6d 6f |ense val|ue in mo|
|00003dc0| 6e 69 74 6f 72 69 6e 67 | 20 74 68 65 20 63 6f 75 |nitoring| the cou|
|00003dd0| 72 73 65 20 6f 66 0d 0a | 70 72 65 74 65 72 6d 20 |rse of..|preterm |
|00003de0| 69 6e 66 61 6e 74 73 20 | 61 73 20 77 65 6c 6c 20 |infants |as well |
|00003df0| 61 73 20 64 65 74 65 72 | 6d 69 6e 69 6e 67 20 66 |as deter|mining f|
|00003e00| 65 61 74 75 72 65 73 20 | 69 6e 64 69 63 61 74 69 |eatures |indicati|
|00003e10| 76 65 20 6f 66 0d 0a 6e | 65 75 72 6f 64 65 76 65 |ve of..n|eurodeve|
|00003e20| 6c 6f 70 6d 65 6e 74 61 | 6c 20 6f 75 74 63 6f 6d |lopmenta|l outcom|
|00003e30| 65 20 28 31 2d 33 29 2e | 20 20 53 75 72 76 69 76 |e (1-3).| Surviv|
|00003e40| 69 6e 67 20 69 6e 66 61 | 6e 74 73 20 62 6f 72 6e |ing infa|nts born|
|00003e50| 20 61 74 20 6c 65 73 73 | 20 74 68 61 6e 20 33 33 | at less| than 33|
|00003e60| 0d 0a 77 65 65 6b 73 27 | 20 67 65 73 74 61 74 69 |..weeks'| gestati|
|00003e70| 6f 6e 20 77 69 74 68 20 | 65 63 68 6f 64 65 6e 73 |on with |echodens|
|00003e80| 69 74 69 65 73 20 61 6e | 64 20 63 79 73 74 73 20 |ities an|d cysts |
|00003e90| 6c 61 72 67 65 72 20 74 | 68 61 6e 20 32 20 6d 6d |larger t|han 2 mm|
|00003ea0| 20 63 6f 6d 70 72 69 73 | 65 20 74 68 65 0d 0a 67 | compris|e the..g|
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|00003f00| 6f 72 20 73 65 76 65 72 | 65 2c 20 61 6e 64 20 63 |or sever|e, and c|
|00003f10| 79 73 74 73 20 6c 61 72 | 67 65 72 20 74 68 61 6e |ysts lar|ger than|
|00003f20| 20 33 20 6d 6d 20 77 65 | 72 65 20 63 6c 61 73 73 | 3 mm we|re class|
|00003f30| 69 66 69 65 64 20 61 73 | 20 6c 61 72 67 65 2c 0d |ified as| large,.|
|00003f40| 0a 74 68 6f 73 65 20 62 | 65 6c 6f 77 20 33 20 6d |.those b|elow 3 m|
|00003f50| 6d 20 61 73 20 73 6d 61 | 6c 6c 2e 20 20 43 79 73 |m as sma|ll. Cys|
|00003f60| 74 69 63 20 63 68 61 6e | 67 65 73 20 77 65 72 65 |tic chan|ges were|
|00003f70| 20 70 61 72 61 6d 6f 75 | 6e 74 20 74 6f 20 74 68 | paramou|nt to th|
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|00003fa0| 20 61 6e 64 20 6f 6e 63 | 65 20 61 67 61 69 6e 20 | and onc|e again |
|00003fb0| 68 61 64 20 74 68 65 20 | 62 65 73 74 20 70 6f 73 |had the |best pos|
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|00004040| 63 74 69 6e 67 20 63 65 | 72 65 62 72 61 6c 20 70 |cting ce|rebral p|
|00004050| 61 6c 73 79 2e 20 20 41 | 6c 6c 20 32 36 20 69 6e |alsy. A|ll 26 in|
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|00004070| 74 69 63 20 63 65 72 65 | 62 72 61 6c 20 70 61 6c |tic cere|bral pal|
|00004080| 73 79 20 68 61 64 20 6c | 65 73 69 6f 6e 73 2c 20 |sy had l|esions, |
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|00004160| 63 68 61 6e 63 65 73 20 | 66 6f 72 20 6d 69 73 72 |chances |for misr|
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|00004180| 63 74 20 69 6e 74 65 72 | 70 72 65 74 61 74 69 6f |ct inter|pretatio|
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|000041b0| 63 72 69 74 69 63 61 6c | 20 61 73 20 74 68 65 20 |critical| as the |
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|00004250| 62 72 61 6c 20 70 61 6c | 73 79 2e 20 20 50 65 72 |bral pal|sy. Per|
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|00004270| 75 6b 6f 6d 61 6c 61 63 | 69 61 20 70 72 6f 62 61 |ukomalac|ia proba|
|00004280| 62 6c 79 20 72 65 73 75 | 6c 74 73 20 66 72 6f 6d |bly resu|lts from|
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|000042c0| 6f 20 28 73 65 65 20 41 | 62 73 74 72 61 63 74 20 |o (see A|bstract |
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|000042f0| 66 20 67 72 65 61 74 20 | 70 72 6f 67 6e 6f 73 74 |f great |prognost|
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|00004350| 20 63 68 61 6e 67 65 73 | 0d 0a 72 65 6d 61 69 6e | changes|..remain|
|00004360| 20 74 6f 20 62 65 20 65 | 6c 75 63 69 64 61 74 65 | to be e|lucidate|
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|000043a0| 72 6f 66 66 2c 0d 0a 4d | 2e 42 2e 42 2e 43 68 2e |roff,..M|.B.B.Ch.|
|000043b0| 0d 0a 24 55 6e 69 71 75 | 65 5f 49 44 7b 59 52 42 |..$Uniqu|e_ID{YRB|
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|000043d0| 68 61 6c 61 6d 69 63 20 | 48 65 6d 6f 72 72 68 61 |halamic |Hemorrha|
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|00004580| 65 6e 2c 20 4d 2e 44 2e | 7d 0d 0a 0d 0a 43 6f 70 |en, M.D.|}....Cop|
|00004590| 79 72 69 67 68 74 20 28 | 43 29 20 59 65 61 72 20 |yright (|C) Year |
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|00004610| 6f 75 73 20 53 79 73 74 | 65 6d 0d 0a 0d 0a 2d 2d |ous Syst|em....--|
|00004620| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004630| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004640| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004650| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004660| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 54 68 |--------|----..Th|
|00004670| 61 6c 61 6d 69 63 20 48 | 65 6d 6f 72 72 68 61 67 |alamic H|emorrhag|
|00004680| 65 20 57 69 74 68 20 49 | 6e 74 72 61 76 65 6e 74 |e With I|ntravent|
|00004690| 72 69 63 75 6c 61 72 20 | 48 65 6d 6f 72 72 68 61 |ricular |Hemorrha|
|000046a0| 67 65 20 69 6e 20 74 68 | 65 20 46 75 6c 6c 2d 54 |ge in th|e Full-T|
|000046b0| 65 72 6d 20 4e 65 77 62 | 6f 72 6e 0d 0a 0d 0a 52 |erm Newb|orn....R|
|000046c0| 6f 6c 61 6e 64 20 45 48 | 3b 20 46 6c 6f 64 6d 61 |oland EH|; Flodma|
|000046d0| 72 6b 20 4f 3b 20 48 69 | 6c 6c 20 41 0d 0a 28 55 |rk O; Hi|ll A..(U|
|000046e0| 6e 69 76 20 6f 66 20 42 | 72 69 74 69 73 68 20 43 |niv of B|ritish C|
|000046f0| 6f 6c 75 6d 62 69 61 3b | 20 42 72 69 74 69 73 68 |olumbia;| British|
|00004700| 20 43 6f 6c 75 6d 62 69 | 61 20 43 68 69 6c 64 72 | Columbi|a Childr|
|00004710| 65 6e 27 73 20 48 6f 73 | 70 2c 20 56 61 6e 63 6f |en's Hos|p, Vanco|
|00004720| 75 76 65 72 29 0d 0a 50 | 65 64 69 61 74 72 69 63 |uver)..P|ediatric|
|00004730| 73 20 38 35 3a 37 33 37 | 2d 37 34 32 2c 20 31 39 |s 85:737|-742, 19|
|00004740| 39 30 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |90..----|--------|
|00004750| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004760| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004770| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004780| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004790| 2d 2d 0d 0a 0d 0a 41 62 | 73 74 72 61 63 74 0d 0a |--....Ab|stract..|
|000047a0| 0d 0a 20 20 20 20 20 49 | 6e 74 72 61 76 65 6e 74 |.. I|ntravent|
|000047b0| 72 69 63 75 6c 61 72 20 | 68 65 6d 6f 72 72 68 61 |ricular |hemorrha|
|000047c0| 67 65 2c 20 61 6c 74 68 | 6f 75 67 68 20 63 6f 6d |ge, alth|ough com|
|000047d0| 6d 6f 6e 20 69 6e 20 70 | 72 65 6d 61 74 75 72 65 |mon in p|remature|
|000047e0| 20 69 6e 66 61 6e 74 73 | 2c 20 69 73 0d 0a 75 6e | infants|, is..un|
|000047f0| 63 6f 6d 6d 6f 6e 20 69 | 6e 20 66 75 6c 6c 2d 74 |common i|n full-t|
|00004800| 65 72 6d 20 6e 65 77 62 | 6f 72 6e 73 2e 20 20 54 |erm newb|orns. T|
|00004810| 68 65 20 63 6c 69 6e 69 | 63 61 6c 20 61 70 70 65 |he clini|cal appe|
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|00004830| 69 6f 6e 73 2c 20 61 6e | 64 0d 0a 72 61 64 69 6f |ions, an|d..radio|
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|00004850| 6e 64 20 73 65 71 75 65 | 6c 61 65 20 61 74 20 31 |nd seque|lae at 1|
|00004860| 38 20 6d 6f 6e 74 68 73 | 20 69 6e 20 61 20 67 72 |8 months| in a gr|
|00004870| 6f 75 70 20 6f 66 20 66 | 75 6c 6c 2d 74 65 72 6d |oup of f|ull-term|
|00004880| 20 6e 65 77 62 6f 72 6e | 73 0d 0a 77 69 74 68 20 | newborn|s..with |
|00004890| 61 6e 20 75 6e 75 73 75 | 61 6c 6c 79 20 68 69 67 |an unusu|ally hig|
|000048a0| 68 20 69 6e 63 69 64 65 | 6e 63 65 20 6f 66 20 74 |h incide|nce of t|
|000048b0| 68 61 6c 61 6d 69 63 20 | 68 65 6d 6f 72 72 68 61 |halamic |hemorrha|
|000048c0| 67 65 20 61 73 73 6f 63 | 69 61 74 65 64 20 77 69 |ge assoc|iated wi|
|000048d0| 74 68 0d 0a 69 6e 74 72 | 61 76 65 6e 74 72 69 63 |th..intr|aventric|
|000048e0| 75 6c 61 72 20 68 65 6d | 6f 72 72 68 61 67 65 20 |ular hem|orrhage |
|000048f0| 77 65 72 65 20 64 65 73 | 63 72 69 62 65 64 2e 0d |were des|cribed..|
|00004900| 0a 20 20 20 20 20 4f 66 | 20 31 39 20 66 75 6c 6c |. Of| 19 full|
|00004910| 2d 74 65 72 6d 20 69 6e | 66 61 6e 74 73 20 77 69 |-term in|fants wi|
|00004920| 74 68 20 69 6e 74 72 61 | 76 65 6e 74 72 69 63 75 |th intra|ventricu|
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|00004940| 69 61 67 6e 6f 73 65 64 | 20 62 79 20 43 54 0d 0a |iagnosed| by CT..|
|00004950| 62 65 66 6f 72 65 20 31 | 20 6d 6f 6e 74 68 20 6f |before 1| month o|
|00004960| 66 20 61 67 65 2c 20 74 | 68 61 6c 61 6d 69 63 20 |f age, t|halamic |
|00004970| 68 65 6d 6f 72 72 68 61 | 67 65 20 77 61 73 20 64 |hemorrha|ge was d|
|00004980| 6f 63 75 6d 65 6e 74 65 | 64 20 69 6e 20 31 32 2e |ocumente|d in 12.|
|00004990| 20 20 4d 6f 73 74 20 6f | 66 20 74 68 65 0d 0a 69 | Most o|f the..i|
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|000049b0| 73 70 6f 73 69 6e 67 20 | 66 61 63 74 6f 72 73 20 |sposing |factors |
|000049c0| 66 6f 72 20 63 65 72 65 | 62 72 61 6c 20 76 65 6e |for cere|bral ven|
|000049d0| 6f 75 73 20 69 6e 66 61 | 72 63 74 69 6f 6e 2c 20 |ous infa|rction, |
|000049e0| 69 6e 63 6c 75 64 69 6e | 67 0d 0a 73 65 70 73 69 |includin|g..sepsi|
|000049f0| 73 2c 20 63 79 61 6e 6f | 74 69 63 20 63 6f 6e 67 |s, cyano|tic cong|
|00004a00| 65 6e 69 74 61 6c 20 68 | 65 61 72 74 20 64 69 73 |enital h|eart dis|
|00004a10| 65 61 73 65 2c 20 61 6e | 64 20 63 6f 61 67 75 6c |ease, an|d coagul|
|00004a20| 6f 70 61 74 68 79 2e 20 | 20 54 68 65 20 63 6c 69 |opathy. | The cli|
|00004a30| 6e 69 63 61 6c 0d 0a 61 | 70 70 65 61 72 61 6e 63 |nical..a|ppearanc|
|00004a40| 65 20 61 6e 64 20 6f 75 | 74 63 6f 6d 65 73 20 66 |e and ou|tcomes f|
|00004a50| 6f 72 20 74 68 65 20 69 | 6e 66 61 6e 74 73 20 77 |or the i|nfants w|
|00004a60| 69 74 68 20 74 68 61 6c | 61 6d 69 63 20 68 65 6d |ith thal|amic hem|
|00004a70| 6f 72 72 68 61 67 65 20 | 61 73 73 6f 63 69 61 74 |orrhage |associat|
|00004a80| 65 64 0d 0a 77 69 74 68 | 20 69 6e 74 72 61 76 65 |ed..with| intrave|
|00004a90| 6e 74 72 69 63 75 6c 61 | 72 20 68 65 6d 6f 72 72 |ntricula|r hemorr|
|00004aa0| 68 61 67 65 20 77 65 72 | 65 20 73 69 6d 69 6c 61 |hage wer|e simila|
|00004ab0| 72 20 74 6f 20 74 68 6f | 73 65 20 6f 66 20 69 6e |r to tho|se of in|
|00004ac0| 66 61 6e 74 73 20 77 69 | 74 68 0d 0a 69 6e 74 72 |fants wi|th..intr|
|00004ad0| 61 76 65 6e 74 72 69 63 | 75 6c 61 72 20 68 65 6d |aventric|ular hem|
|00004ae0| 6f 72 72 68 61 67 65 20 | 6f 72 69 67 69 6e 61 74 |orrhage |originat|
|00004af0| 69 6e 67 20 66 72 6f 6d | 20 6f 74 68 65 72 20 73 |ing from| other s|
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|00004b10| 74 68 65 72 65 20 77 61 | 73 0d 0a 61 6e 20 69 6e |there wa|s..an in|
|00004b20| 63 72 65 61 73 65 64 20 | 69 6e 63 69 64 65 6e 63 |creased |incidenc|
|00004b30| 65 20 6f 66 20 63 65 72 | 65 62 72 61 6c 20 70 61 |e of cer|ebral pa|
|00004b40| 6c 73 79 20 69 6e 20 69 | 6e 66 61 6e 74 73 20 77 |lsy in i|nfants w|
|00004b50| 69 74 68 20 74 68 61 6c | 61 6d 69 63 20 68 65 6d |ith thal|amic hem|
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|00004b80| 6e 74 72 69 63 75 6c 61 | 72 20 68 65 6d 6f 72 72 |ntricula|r hemorr|
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|00004bf0| 6f 6d 61 6c 69 65 73 20 | 28 46 69 67 20 37 2d 34 |omalies |(Fig 7-4|
|00004c00| 2c 0d 0a 74 61 62 6c 65 | 29 2e 0d 0a 20 20 20 20 |,..table|)... |
|00004c10| 20 54 68 61 6c 61 6d 69 | 63 20 68 65 6d 6f 72 72 | Thalami|c hemorr|
|00004c20| 68 61 67 65 20 73 65 65 | 6d 73 20 74 6f 20 62 65 |hage see|ms to be|
|00004c30| 20 74 68 65 20 6d 6f 73 | 74 20 63 6f 6d 6d 6f 6e | the mos|t common|
|00004c40| 20 73 6f 75 72 63 65 20 | 6f 66 0d 0a 69 6e 74 72 | source |of..intr|
|00004c50| 61 76 65 6e 74 72 69 63 | 75 6c 61 72 20 68 65 6d |aventric|ular hem|
|00004c60| 6f 72 72 68 61 67 65 20 | 69 6e 20 66 75 6c 6c 2d |orrhage |in full-|
|00004c70| 74 65 72 6d 20 69 6e 66 | 61 6e 74 73 2c 20 65 73 |term inf|ants, es|
|00004c80| 70 65 63 69 61 6c 6c 79 | 20 69 6e 20 74 68 6f 73 |pecially| in thos|
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|00004cd0| 6e 6f 72 6d 61 6c 69 74 | 69 65 73 20 64 65 76 65 |normalit|ies deve|
|00004ce0| 6c 6f 70 65 64 0d 0a 61 | 66 74 65 72 20 74 68 65 |loped..a|fter the|
|00004cf0| 20 66 69 72 73 74 20 77 | 65 65 6b 20 6f 66 20 6c | first w|eek of l|
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|00004d50| 20 6f 6e 20 43 54 20 73 | 63 61 6e 73 2c 20 63 72 | on CT s|cans, cr|
|00004d60| 61 6e 69 61 6c 20 75 6c | 74 72 61 73 6f 6e 6f 67 |anial ul|trasonog|
|00004d70| 72 61 70 68 79 2c 20 6f | 72 20 63 65 72 65 62 72 |raphy, o|r cerebr|
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|00004d90| 20 20 4e 65 75 72 6f 6c | 6f 67 69 63 20 73 65 71 | Neurol|ogic seq|
|00004da0| 75 65 6c 61 65 20 6f 63 | 63 75 72 20 63 6f 6d 6d |uelae oc|cur comm|
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|00004dc0| 20 6d 69 6e 6f 72 69 74 | 79 20 6f 66 20 74 68 65 | minorit|y of the|
|00004dd0| 0d 0a 69 6e 66 61 6e 74 | 73 20 61 70 70 65 61 72 |..infant|s appear|
|00004de0| 65 64 20 6e 65 75 72 6f | 6c 6f 67 69 63 61 6c 6c |ed neuro|logicall|
|00004df0| 79 20 61 6e 64 20 64 65 | 76 65 6c 6f 70 6d 65 6e |y and de|velopmen|
|00004e00| 74 61 6c 6c 79 20 6e 6f | 72 6d 61 6c 20 61 74 20 |tally no|rmal at |
|00004e10| 31 38 20 6d 6f 6e 74 68 | 73 20 6f 66 0d 0a 61 67 |18 month|s of..ag|
|00004e20| 65 2e 0d 0a 0d 0a 50 6f | 73 74 2d 43 6f 6d 6d 65 |e.....Po|st-Comme|
|00004e30| 6e 74 0d 0a 0d 0a 20 20 | 20 20 20 43 6f 6d 6d 65 |nt.... | Comme|
|00004e40| 6e 74 69 6e 67 20 6f 6e | 20 74 68 69 73 20 61 72 |nting on| this ar|
|00004e50| 74 69 63 6c 65 20 69 73 | 20 4d 61 6a 65 65 64 20 |ticle is| Majeed |
|00004e60| 41 6c 2d 4d 61 74 65 65 | 6e 2c 20 4d 2e 44 2e 2c |Al-Matee|n, M.D.,|
|00004e70| 20 44 69 72 65 63 74 6f | 72 2c 0d 0a 4e 65 75 72 | Directo|r,..Neur|
|00004e80| 6f 6c 6f 67 79 2c 20 43 | 68 69 6c 64 72 65 6e 27 |ology, C|hildren'|
|00004e90| 73 20 48 6f 73 70 69 74 | 61 6c 20 4f 61 6b 6c 61 |s Hospit|al Oakla|
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|00004eb0| 0a 20 20 20 20 20 54 68 | 65 20 61 75 74 68 6f 72 |. Th|e author|
|00004ec0| 73 27 20 63 6f 6e 63 6c | 75 73 69 6f 6e 20 74 68 |s' concl|usion th|
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|00004f10| 69 6e 74 72 61 76 65 6e | 74 72 69 63 75 6c 61 72 |intraven|tricular|
|00004f20| 20 68 65 6d 6f 72 72 68 | 61 67 65 20 69 6e 20 66 | hemorrh|age in f|
|00004f30| 75 6c 6c 2d 74 65 72 6d | 20 69 6e 66 61 6e 74 73 |ull-term| infants|
|00004f40| 20 69 73 20 61 0d 0a 64 | 65 70 61 72 74 75 72 65 | is a..d|eparture|
|00004f50| 20 66 72 6f 6d 20 74 68 | 65 20 6c 61 72 67 65 6c | from th|e largel|
|00004f60| 79 20 68 65 6c 64 20 76 | 69 65 77 20 74 68 61 74 |y held v|iew that|
|00004f70| 20 69 6e 20 74 68 65 20 | 66 75 6c 6c 2d 74 65 72 | in the |full-ter|
|00004f80| 6d 20 69 6e 66 61 6e 74 | 0d 0a 69 6e 74 72 61 76 |m infant|..intrav|
|00004f90| 65 6e 74 72 69 63 75 6c | 61 72 20 68 65 6d 6f 72 |entricul|ar hemor|
|00004fa0| 72 68 61 67 65 20 61 72 | 69 73 65 73 20 70 72 69 |rhage ar|ises pri|
|00004fb0| 6d 61 72 69 6c 79 20 66 | 72 6f 6d 20 62 6c 65 65 |marily f|rom blee|
|00004fc0| 64 69 6e 67 20 69 6e 20 | 74 68 65 20 63 68 6f 72 |ding in |the chor|
|00004fd0| 6f 69 64 0d 0a 70 6c 65 | 78 75 73 2e 20 20 54 77 |oid..ple|xus. Tw|
|00004fe0| 6f 20 6d 61 6a 6f 72 20 | 70 61 74 68 6f 67 65 6e |o major |pathogen|
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|00005010| 72 6f 6c 65 20 69 6e 0d | 0a 69 6e 74 72 61 76 65 |role in.|.intrave|
|00005020| 6e 74 72 69 63 75 6c 61 | 72 20 68 65 6d 6f 72 72 |ntricula|r hemorr|
|00005030| 68 61 67 65 20 69 6e 20 | 74 68 65 20 74 65 72 6d |hage in |the term|
|00005040| 20 6e 65 6f 6e 61 74 65 | 2c 20 69 2e 65 2e 2c 20 | neonate|, i.e., |
|00005050| 74 72 61 75 6d 61 20 61 | 6e 64 20 70 65 72 69 6e |trauma a|nd perin|
|00005060| 61 74 61 6c 0d 0a 68 79 | 70 6f 78 69 63 2d 69 73 |atal..hy|poxic-is|
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|00005080| 65 72 65 20 6e 6f 74 20 | 61 70 70 6c 69 63 61 62 |ere not |applicab|
|00005090| 6c 65 20 74 6f 20 74 68 | 65 20 63 61 73 65 73 20 |le to th|e cases |
|000050a0| 69 6e 20 74 68 69 73 20 | 73 65 72 69 65 73 2e 20 |in this |series. |
|000050b0| 20 54 68 65 0d 0a 64 61 | 74 61 20 73 75 67 67 65 | The..da|ta sugge|
|000050c0| 73 74 20 74 68 61 74 20 | 63 6f 61 67 75 6c 6f 70 |st that |coagulop|
|000050d0| 61 74 68 79 20 61 6e 64 | 20 73 65 70 73 69 73 20 |athy and| sepsis |
|000050e0| 72 61 6e 6b 20 68 69 67 | 68 65 73 74 20 61 6d 6f |rank hig|hest amo|
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|00005100| 0a 70 72 65 64 69 73 70 | 6f 73 69 6e 67 20 66 61 |.predisp|osing fa|
|00005110| 63 74 6f 72 73 20 74 6f | 20 74 68 61 6c 61 6d 69 |ctors to| thalami|
|00005120| 63 20 68 65 6d 6f 72 72 | 68 61 67 65 2e 20 20 56 |c hemorr|hage. V|
|00005130| 65 6e 6f 75 73 20 6f 63 | 63 6c 75 73 69 6f 6e 20 |enous oc|clusion |
|00005140| 69 6e 76 6f 6c 76 69 6e | 67 20 74 68 65 0d 0a 69 |involvin|g the..i|
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|000056e0| 45 64 69 74 6f 72 7b 44 | 72 73 2e 20 4b 6c 61 75 |Editor{D|rs. Klau|
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|00005730| 67 68 74 20 28 43 29 20 | 59 65 61 72 20 42 6f 6f |ght (C) |Year Boo|
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|00005760| 0a 0d 0a 31 39 39 31 20 | 59 65 61 72 20 42 6f 6f |...1991 |Year Boo|
|00005770| 6b 20 6f 66 20 4e 65 6f | 6e 61 74 61 6c 20 61 6e |k of Neo|natal an|
|00005780| 64 20 50 65 72 69 6e 61 | 74 61 6c 20 4d 65 64 69 |d Perina|tal Medi|
|00005790| 63 69 6e 65 0d 0a 0d 0a | 43 68 61 70 74 65 72 20 |cine....|Chapter |
|000057a0| 37 20 2d 2d 20 54 68 65 | 20 4e 65 72 76 6f 75 73 |7 -- The| Nervous|
|000057b0| 20 53 79 73 74 65 6d 0d | 0a 0d 0a 2d 2d 2d 2d 2d | System.|...-----|
|000057c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000057f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 46 72 65 71 75 |--------|-..Frequ|
|00005810| 65 6e 74 20 48 61 6e 64 | 6c 69 6e 67 20 69 6e 20 |ent Hand|ling in |
|00005820| 74 68 65 20 4e 65 6f 6e | 61 74 61 6c 20 49 6e 74 |the Neon|atal Int|
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|00005860| 65 0d 0a 0d 0a 42 61 64 | 61 20 48 53 3b 20 4b 6f |e....Bad|a HS; Ko|
|00005870| 72 6f 6e 65 73 20 53 42 | 3b 20 50 65 72 72 79 20 |rones SB|; Perry |
|00005880| 45 48 3b 20 41 72 68 65 | 61 72 74 20 4b 4c 3b 20 |EH; Arhe|art KL; |
|00005890| 50 6f 75 72 63 79 72 6f | 75 73 20 4d 3b 20 52 75 |Pourcyro|us M; Ru|
|000058a0| 6e 79 61 6e 20 4a 57 20 | 49 49 49 3b 0d 0a 41 6e |nyan JW |III;..An|
|000058b0| 64 65 72 73 6f 6e 20 47 | 44 3b 20 4d 61 67 69 6c |derson G|D; Magil|
|000058c0| 6c 20 48 4c 3b 20 46 69 | 74 63 68 20 43 57 3b 20 |l HL; Fi|tch CW; |
|000058d0| 53 6f 6d 65 73 20 47 57 | 0d 0a 28 55 6e 69 76 20 |Somes GW|..(Univ |
|000058e0| 6f 66 20 54 65 6e 6e 65 | 73 73 65 65 2c 20 4d 65 |of Tenne|ssee, Me|
|000058f0| 6d 70 68 69 73 3b 20 4d | 65 6d 70 68 69 73 20 53 |mphis; M|emphis S|
|00005900| 74 61 74 65 20 55 6e 69 | 76 29 0d 0a 4a 20 50 65 |tate Uni|v)..J Pe|
|00005910| 64 69 61 74 72 20 31 31 | 37 3a 31 32 36 2d 31 33 |diatr 11|7:126-13|
|00005920| 31 2c 20 31 39 39 30 0d | 0a 2d 2d 2d 2d 2d 2d 2d |1, 1990.|.-------|
|00005930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005ee0| 65 63 72 65 61 73 65 64 | 20 69 6e 20 62 6f 74 68 |ecreased| in both|
|00005ef0| 20 67 72 6f 75 70 73 2e | 20 20 42 79 20 74 68 65 | groups.| By the|
|00005f00| 20 66 69 66 74 68 20 64 | 61 79 20 6f 66 20 6c 69 | fifth d|ay of li|
|00005f10| 66 65 2c 20 37 36 25 20 | 6f 66 20 74 68 65 0d 0a |fe, 76% |of the..|
|00005f20| 73 74 75 64 79 20 67 72 | 6f 75 70 27 73 20 64 61 |study gr|oup's da|
|00005f30| 79 20 77 61 73 20 73 70 | 65 6e 74 20 61 74 20 72 |y was sp|ent at r|
|00005f40| 65 73 74 2c 20 63 6f 6d | 70 61 72 65 64 20 77 69 |est, com|pared wi|
|00005f50| 74 68 20 37 33 25 20 6f | 66 20 74 68 65 20 63 6f |th 73% o|f the co|
|00005f60| 6e 74 72 6f 6c 20 67 72 | 6f 75 70 27 73 0d 0a 64 |ntrol gr|oup's..d|
|00005f70| 61 79 2e 0d 0a 20 20 20 | 20 20 54 68 65 20 69 6e |ay... | The in|
|00005f80| 63 69 64 65 6e 63 65 20 | 6f 66 20 67 72 61 64 65 |cidence |of grade|
|00005f90| 73 20 32 20 74 6f 20 34 | 20 6f 72 20 73 65 76 65 |s 2 to 4| or seve|
|00005fa0| 72 65 20 50 56 2d 49 56 | 48 20 64 69 64 20 6e 6f |re PV-IV|H did no|
|00005fb0| 74 20 64 69 66 66 65 72 | 0d 0a 73 69 67 6e 69 66 |t differ|..signif|
|00005fc0| 69 63 61 6e 74 6c 79 20 | 62 65 74 77 65 65 6e 20 |icantly |between |
|00005fd0| 74 68 65 20 73 74 75 64 | 79 20 61 6e 64 20 63 6f |the stud|y and co|
|00005fe0| 6e 74 72 6f 6c 20 67 72 | 6f 75 70 73 2e 20 20 41 |ntrol gr|oups. A|
|00005ff0| 74 20 61 67 65 20 32 34 | 20 68 6f 75 72 73 20 67 |t age 24| hours g|
|00006000| 72 61 64 65 73 20 32 0d | 0a 74 6f 20 34 20 50 56 |rades 2.|.to 4 PV|
|00006010| 2d 49 56 48 20 77 65 72 | 65 20 6e 6f 74 65 64 20 |-IVH wer|e noted |
|00006020| 69 6e 20 31 33 25 20 6f | 66 20 74 68 65 20 73 74 |in 13% o|f the st|
|00006030| 75 64 79 20 67 72 6f 75 | 70 20 61 6e 64 20 31 38 |udy grou|p and 18|
|00006040| 25 20 6f 66 20 74 68 65 | 20 63 6f 6e 74 72 6f 6c |% of the| control|
|00006050| 20 67 72 6f 75 70 2e 0d | 0a 44 61 69 6c 79 20 63 | group..|.Daily c|
|00006060| 75 6d 75 6c 61 74 69 76 | 65 20 69 6e 63 69 64 65 |umulativ|e incide|
|00006070| 6e 63 65 20 64 69 64 20 | 6e 6f 74 20 64 69 66 66 |nce did |not diff|
|00006080| 65 72 20 62 65 74 77 65 | 65 6e 20 67 72 6f 75 70 |er betwe|en group|
|00006090| 73 20 6e 6f 72 20 64 69 | 64 20 74 68 65 20 6d 65 |s nor di|d the me|
|000060a0| 61 6e 20 61 67 65 0d 0a | 61 74 20 74 68 65 20 74 |an age..|at the t|
|000060b0| 69 6d 65 20 6f 66 20 65 | 78 74 65 6e 73 69 6f 6e |ime of e|xtension|
|000060c0| 20 6f 66 20 74 68 65 20 | 50 56 2d 49 56 48 2e 20 | of the |PV-IVH. |
|000060d0| 20 53 65 76 65 72 65 20 | 50 56 2d 49 56 48 20 6f | Severe |PV-IVH o|
|000060e0| 63 63 75 72 72 65 64 20 | 69 6e 20 31 30 25 20 6f |ccurred |in 10% o|
|000060f0| 66 20 74 68 65 0d 0a 73 | 74 75 64 79 20 67 72 6f |f the..s|tudy gro|
|00006100| 75 70 20 61 6e 64 20 69 | 6e 20 31 33 25 20 6f 66 |up and i|n 13% of|
|00006110| 20 74 68 65 20 63 6f 6e | 74 72 6f 6c 20 67 72 6f | the con|trol gro|
|00006120| 75 70 2e 20 20 54 68 65 | 20 63 6c 69 6e 69 63 61 |up. The| clinica|
|00006130| 6c 20 63 6f 75 72 73 65 | 20 6f 66 20 74 68 65 0d |l course| of the.|
|00006140| 0a 69 6e 66 61 6e 74 73 | 20 61 73 73 69 67 6e 65 |.infants| assigne|
|00006150| 64 20 74 6f 20 74 68 65 | 20 73 74 75 64 79 20 61 |d to the| study a|
|00006160| 6e 64 20 63 6f 6e 74 72 | 6f 6c 20 67 72 6f 75 70 |nd contr|ol group|
|00006170| 73 20 77 61 73 20 73 69 | 6d 69 6c 61 72 2e 20 20 |s was si|milar. |
|00006180| 54 68 65 20 6d 6f 72 74 | 61 6c 69 74 79 0d 0a 61 |The mort|ality..a|
|00006190| 6e 64 20 6d 6f 72 62 69 | 64 69 74 79 20 6f 66 20 |nd morbi|dity of |
|000061a0| 74 68 65 20 32 20 67 72 | 6f 75 70 73 20 69 6e 20 |the 2 gr|oups in |
|000061b0| 74 68 65 20 6e 65 6f 6e | 61 74 61 6c 20 70 65 72 |the neon|atal per|
|000061c0| 69 6f 64 20 61 72 65 20 | 63 6f 6d 70 61 72 65 64 |iod are |compared|
|000061d0| 20 69 6e 20 74 68 65 0d | 0a 74 61 62 6c 65 2e 0d | in the.|.table..|
|000061e0| 0a 20 20 20 20 20 4c 6f | 77 20 62 69 72 74 68 20 |. Lo|w birth |
|000061f0| 77 65 69 67 68 74 20 61 | 6e 64 20 6c 6f 77 20 35 |weight a|nd low 5|
|00006200| 2d 6d 69 6e 75 74 65 20 | 41 70 67 61 72 20 73 63 |-minute |Apgar sc|
|00006210| 6f 72 65 73 20 77 65 72 | 65 20 73 69 67 6e 69 66 |ores wer|e signif|
|00006220| 69 63 61 6e 74 0d 0a 70 | 72 65 64 69 63 74 69 76 |icant..p|redictiv|
|00006230| 65 20 76 61 72 69 61 62 | 6c 65 73 20 66 6f 72 20 |e variab|les for |
|00006240| 74 68 65 20 64 65 76 65 | 6c 6f 70 6d 65 6e 74 20 |the deve|lopment |
|00006250| 6f 66 20 73 65 76 65 72 | 65 20 50 56 2d 49 56 48 |of sever|e PV-IVH|
|00006260| 2e 20 20 54 68 65 73 65 | 20 66 69 6e 64 69 6e 67 |. These| finding|
|00006270| 73 0d 0a 61 6c 73 6f 20 | 75 6e 64 65 72 73 63 6f |s..also |undersco|
|00006280| 72 65 64 20 74 68 65 20 | 72 6f 6c 65 20 6f 66 20 |red the |role of |
|00006290| 70 72 65 6d 61 74 75 72 | 69 74 79 20 61 6e 64 20 |prematur|ity and |
|000062a0| 61 73 70 68 79 78 69 61 | 20 69 6e 20 74 68 65 20 |asphyxia| in the |
|000062b0| 70 61 74 68 6f 67 65 6e | 65 73 69 73 20 6f 66 0d |pathogen|esis of.|
|000062c0| 0a 50 56 2d 49 56 48 2e | 0d 0a 20 20 20 20 20 4e |.PV-IVH.|.. N|
|000062d0| 6f 20 72 65 6c 61 74 69 | 6f 6e 73 68 69 70 20 62 |o relati|onship b|
|000062e0| 65 74 77 65 65 6e 20 66 | 72 65 71 75 65 6e 74 20 |etween f|requent |
|000062f0| 68 61 6e 64 6c 69 6e 67 | 20 61 6e 64 20 50 56 2d |handling| and PV-|
|00006300| 49 56 48 20 77 61 73 20 | 64 65 6d 6f 6e 73 74 72 |IVH was |demonstr|
|00006310| 61 74 65 64 2c 0d 0a 65 | 76 65 6e 20 77 68 65 6e |ated,..e|ven when|
|00006320| 20 6f 74 68 65 72 20 70 | 65 72 69 6e 61 74 61 6c | other p|erinatal|
|00006330| 20 72 69 73 6b 20 66 61 | 63 74 6f 72 73 20 77 65 | risk fa|ctors we|
|00006340| 72 65 20 74 61 6b 65 6e | 20 69 6e 74 6f 20 61 63 |re taken| into ac|
|00006350| 63 6f 75 6e 74 2e 20 20 | 54 68 65 20 6f 76 65 72 |count. |The over|
|00006360| 61 6c 6c 0d 0a 72 69 73 | 6b 20 6f 66 20 50 56 2d |all..ris|k of PV-|
|00006370| 49 56 48 20 69 73 20 73 | 69 67 6e 69 66 69 63 61 |IVH is s|ignifica|
|00006380| 6e 74 6c 79 20 61 66 66 | 65 63 74 65 64 20 62 79 |ntly aff|ected by|
|00006390| 20 6c 6f 77 20 62 69 72 | 74 68 20 77 65 69 67 68 | low bir|th weigh|
|000063a0| 74 20 61 6e 64 20 66 61 | 63 74 6f 72 73 0d 0a 69 |t and fa|ctors..i|
|000063b0| 6e 64 69 63 61 74 69 76 | 65 20 6f 66 20 70 65 72 |ndicativ|e of per|
|000063c0| 69 6e 61 74 61 6c 20 61 | 73 70 68 79 78 69 61 2e |inatal a|sphyxia.|
|000063d0| 0d 0a 0d 0a 50 6f 73 74 | 2d 43 6f 6d 6d 65 6e 74 |....Post|-Comment|
|000063e0| 0d 0a 0d 0a 20 20 20 20 | 20 45 66 66 6f 72 74 73 |.... | Efforts|
|000063f0| 20 61 74 20 70 72 65 76 | 65 6e 74 69 6f 6e 20 6f | at prev|ention o|
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